谭蔚泓课题组成果

科研项目

1. 新型冠状病毒（2019-nCov）核酸现场快速检测设备及试剂的研发，国家重点研发计划，负责人：谭蔚泓
2. 家庭简易式新型冠状病毒感染自查技术与试剂盒，上海交通大学医工交叉重点项目，负责人：谭蔚泓
3. 新型冠状病毒诊断与治疗创新产品研发，企业项目（上海之江生物科技股份有限公司），负责人：谭蔚泓
4. 上海交通大学分子医学研究中心，上海交通大学融合集成创新基金交叉平台项目，负责人：谭蔚泓
5. 功能核酸单轮筛选科学装置，国家自然科学基金重大科研仪器研制项目，负责人：谭蔚泓
6. 靶向肿瘤转移节点分子的多模块可编程纳米药物，国家重点研发计划“纳米科技”专项，负责人：肖泽宇
7. 螺旋寡聚芳香酰胺类大环分子的合成及其分子识别行为，国家自然科学基金青年项目，负责人：王翔
8. 肺癌特异性核酸适体药物复合物的构建及机理研究，国家自然科学基金青年项目，负责人：孙洋。
9. α6β4核酸适体拉曼纳米探针识别单细胞外囊泡用于乳腺癌肺转移的诊断研究，国家自然科学青年科学基金项目，负责人：雷豪志。
10. 智能响应型糖基碳量子点用于靶向光驱动治疗类风湿性关节炎,上海市科学技术委员会“扬帆计划”项目，负责人，姬丁坤。
11. 核酸适体催化剂的开发及其在靶蛋白修饰中的应用研究，第67批中国博士后科学基金面上资助，负责人：陈思凯。
12. 金团簇-核酸适体药物偶联物纳米组装体用于肿瘤靶向诊治，2020中国博士后科学基金68批面上资助。负责人：夏芳芳。
13. 核酸适配体碳量子点的可控性制备及肿瘤靶向作用机制研究，中国博士后科学基金第 2 批特别资助（站前），负责人：张卿

发表文章

1. Ya Zhang, Yingjie Wang, Xueqin Yang, Qinglai Yang, Juan Li*, Weihong Tan*. Polyaniline Nanovesicles for Photoacoustic Imaging‐Guided Photothermal‐Chemo Synergistic Therapy in the Second Near‐Infrared Window. Small, 2020, 16(35).
2. Yang Sun, Fei Gao, Cai Yang, Yingying Li, Cheng Jin, Sitao Xie, Cheng Lv, Ding Ding, Da Han, Juan Li, Ruowen Wang*, Weihong Tan*. Construction of Bispecific Aptamer–Drug Conjugate by a Hybrid Chemical and Biological Approach. Chem. 2020, 31, 1289-1294.
3. Kaiming Chen, Jie Zhou, Zhentao Shao, Jia Liu, Jia Song, Ruowen Wang*, Juan Li*, Weihong Tan*. Aptamers as Versatile Molecular Tools for Antibody Production Monitoring and Quality Control. Am. Chem. Soc. 2020, 142, 12079–12086.
4. Cheng Lv, Xiyao Gu, Haowen Li, Yumeng Zhao, Donglei Yang, Weifeng Yu, Da Han*, Juan Li*, Weihong Tan*. Molecular Transport through a Biomimetic DNA Channel on Live Cell Membranes. ACS Nano. 2020, 14(11):14616-14626.
5. Yu Yang, Jiaxuan He, Wenjun Zhu, Xiaoshu Pan, Hoda Safari Yazd, Cheng Cui, Lu Yang, Xiaowei Li, Long Li, Liang Cheng, Liangzhu Feng, Ruowen Wang, Zhuang Liu*, Meiwan Chen*, Weihong Tan*. Molecular domino reactor built by automated modular synthesis for cancer treatment. Theranostics, 2020, 10, 4030-4041.
6. Yu Yang，Xiaoqi Sun，Jun Xu，Cheng Cui，Weihong Tan*. Circular bispecific Aptamer-mediated targeted cellular immunotherapy. ACS Nano, 2020, 14(8):9562-9571.
7. Yu Yang, Zhuang Liu*. Chemiluminescent Nanosystems for Imaging Cancer Chemodynamic Therapy.Chem, 2020,6 (9), 2127-2129.
8. Huarong Bai^#，Cheng Jin^#，Jianmei Zou，Ruowen Wang，Ting Fu*, Weihong Tan*. Conformational Conversion Enhances Cellular Uptake of F Base Double-Strand-Conjugated Oligonucleotides, Chem. 2020, 92, 15, 10375-10380.
9. Cheng Jin, Jiaxuan He, Jianmei Zou, Wenjing Xuan, Ting Fu, Ruowen Wang , Weihong Tan*. Phosphorylated Lipid-Conjugated Oligonucleotide Selectively Anchors on Cell Membranes with High Alkaline Phosphatase Expression. Commun. 2019, 10, 2704.
10. Ding Ding, Da Han, Juan Li, Weihong Tan. Improving early detection of cancers by profiling extracellular vesicles. Expert Review of Proteomics 2019, 16, 545-547.
11. Ding Ding, Cai Yang, Cheng Lv, Juan Li and Weihong Tan. Improving Tumor Accumulation of Aptamers by Prolonged Blood Circulation. Chem. 2020, 5, 4108-4114.
12. Yang Sun, Zhengyu Deng, Yanlan Liu*, Weihong Tan*. Unlocking multiplexing in deep tissue. China Chem., 2018, 13(10):941-946..
13. Yang Sun, Fei Gao, Cai Yang, Yingying Li, Cheng Jin, Sitao Xie, Da Han, Ruowen Wang*, Weihong Tan*. Design and synthesis of Bispecific aptamer-drug conjugate for targeted cancer therapy. Chem. 2020, 31.
14. Yifan Lyu, Yian Guo, Ren Cai, Ruizi Peng, Chengyi Hong, Xigao Chen, Weijia Hou, Xiaowei Li, Jie Tan, Yuxiu Zou, Xiaobing Zhang, Qiaoling Liu, Weihong Tan*. Spherically directed synthesis and enhanced cellular internalization of metal-crosslinked DNA micelles. Chem, 2019, 5, 1-16.
15. Yuan Liu, Yu Yang, Yujia Sun, Jibin Song, Nicholas Rudawski, Xiaoyuan Chen, Weihong Tan*. Ostwald ripening-mediated grafting of metal-organic frameworks on a single colloidal nanocrystal to form uniform and controllable MXF. Am. Chem. Soc., 2019, 141(18):7407-7413.
16. Hui Liu, Qiuxia Yang, Ruizi Peng, Hailan Kuai, Yifan Lyu, Xiaoshu Pan, Qiaoling Liu*, Weihong Tan*. Artificial signal feedback network mimicking cellular adaptivity. Am. Chem. Soc. 2019, 141, 6458-6461 .
17. Lili Zhang, Razack Abdullah, XiaoXiao Hu, Huarong Bai, Huanhuan Fan, Lei He, Hao Liang, Jianmei Zou, Yanlan Liu, Yang Sun, Xiaobing Zhang*, Weihong Tan*. Engineering of bioinspired, size-controllable and self-degradable cancertargeting DNA nanoflowers via incorporation of an artificial sandwich base. Am. Chem. Soc. 2019, 141, 4282-4290.
18. Ren Cai#, Dan Yang#, Keng-Te Lin, Yifan Lyu, Bowen Zhu, Zhen He, Lili Zhang, Yusuke Kitamura, Liping Qiu, Yuliang Zhao, Zhuo Chen*, Weihong Tan*. Generalized preparation of 2D quasi-nanosheets via self-assembly of nanoparticles, Am. Chem. Soc. 2019, 141,1725-1734.
19. Jie Tan, Mengmeng Zhao, Jie Wang, Zhihao Li, Ling Liang, Liqin Zhang, Quan Yuan,* Weihong Tan*. Regulation of protein activity and cellular functions mediated by molecularly evolved nucleic acids, Chem. Int. Ed. 2019, 58, 1621-1625.
20. Li Tian, Mengke Su, Fanfan Yu, Yue Xu, Xiaoyun Li, Lei Li, Honglin Liu*, Weihong Tan*. Liquid-state quantitative SERS analyzer on self-ordered metal liquid-like plasmonic arrays. Commun, 2018, 9, 3642.
21. Tanggang Deng#, Guobei Yan#, Xin Song#, Lin Xie, Yu Zhou, Jianglin Li, Xiaoxiao Hu, Zhen Li, Jun Hu, Yibin Zhang, Hui Zhang, Yang Sun, Peifu Feng, Dong Wei, Bin Hu, Jing Liu*, Weihong Tan*, Mao Ye*. Deubiquitylation and stabilization of p21 by USP11 is critical for cell cycle progression and DNA damage responses. Natl. Acad. Sci. USA 2018, 115, 4678-4683.
22. Long Li, Ying Jiang, Cheng Cui, Yu Yang, Penghui Zhang, Kimberly Stewart, Xiaoshu Pan, Xiaowei Li, Lu Yang, Liping Qiu*, Weihong Tan*. Modulating aptamer specificity with pH-responsive DNA bonds. Am. Chem. Soc. 2018, 140, 13335-13339.
23. I-Ting Teng#, Xiaowei Li#, Hamad Yadikar, Zhihui Yang, Long Li, Yifan Lyu, Xiaoshu Pan, Kevin Wang*, Weihong Tan*. Identification and characterization of DNA aptamers specific for phosphorylation epitopes of Tau protein Am. Chem. Soc, 2018, 140, 14314-14323.
24. Ruizi Peng#, Xiaofang Zheng#, Yifan Lyu, Liujun Xu, Xiao-Bing Zhang, Guoliang Ke, Qiaoling Liu, Changjun You, Shuangyan Huan*, Weihong Tan*. Engineering a 3D DNA-logic gate nanomachine for bispecific recognition and computing on target cell surface. Am. Chem. Soc. 2018, 140, 9793-9796.
25. Ying Jiang, Xiaoshu Pan, Jin Chang, Weijia Niu, Weijia Hou, Hailan Kuai, Zilong Zhao*, Ji Liu, Ming Wang*, Weihong Tan*. Supramolecularly engineered circular bivalent aptamer for enhanced functional protein delivery. Am. Chem. Soc. 2018, 140, 6780-6784.
26. Yifan Lyu, Cuichen Wu, Charles Heinke, Da Han, Ren Cai, I-Ting Teng, Yuan Liu, Hui Liu, Xiao-Bing Zhang, Qiaoling Liu, Weihong Tan*. Constructing smart protocells with built-in DNA computational core to eliminate exogenous challenge. Am. Chem. Soc. 2018, 140, 6912-6920.
27. Yuan Wu, Liqin Zhang, Cheng Cui, Sena Cansiz, Hao Liang, Cuichen Wu, I-Ting Teng, Weijun Chen, Yuan Liu, Weijia Hou, Xiaobing Zhang*, Weihong Tan*. Enhanced targeted gene transduction: AAV2 vectors conjugated to multiple aptamers via reducible disulfide linkages. Am. Chem. Soc. 2018, 140, 2-5.
28. Lei He, Danqing Lu, Hao Liang, Sitao Xie, Xiaobing Zhang, Qiaoling Liu, Quan Yuan*, Weihong Tan*. A mRNA-initiated, three-dimensional DNA amplifier able to function inside living cells. Am. Chem. Soc. 2018, 140, 258-263.
29. Hong Liang, Shan Chen, Peipei Li, Liping Wang, Jingying Li, Juan Li*, Huang-Hao Yang*, Weihong Tan*. Nongenetic approach for imaging protein dimerization by aptamer recognition and proximity-induced DNA assembly. Am. Chem. Soc. 2018, 140, 4186-4190.
30. Lu Yang, Hao Sun, Dr. Yuan Liu, Weijia Hou, Yu Yang, Ren Cai, Cheng Cui, Penghui Zhang, Xiaoshu Pan, Xiaowei Li, Long Li, Brent S. Sumerlin*, Weihong Tan*. Self-assembled aptamer-hyperbranched polymer nanocarrier for targeted and photoresponsive drug delivery. Chem. Int. Ed. 2018, 57, 17048-17052.
31. Xiaowei Li, Ruowen Wang, Ying Jiang, Yifan Lyu, Hao Sun, Yuan Liu, Yanyue Wang, I-Ting Teng, Weijia Hou, Ren Cai, Cheng Cui, Long Li, Xiaoshu Pan, Brent S. Sumerlin, Weihong Tan*. Cross-linked aptamer-lipid micelles for excellent stability and specificity in target cell recognition. Chem. Int. Ed. 2018, 57, 11763-11767.
32. Cheng Jin #, Hui Zhang#, Jianmei Zou, Yan Liu, Lin Zhang, Fengjie Li, Ruowen Wang, Wenjing Xuan, Mao Ye*, Weihong Tan*. Floxuridine homomeric oligonucleotides “Hitchhike” with albumin in situ for cancer chemotherapy. Angew. Chem. Int. Ed. 2018, 57, 8994-8997.

授权专利

1. 谭蔚泓、刘庄、肖泽宇、孙洋；核酸类衍生物改性的核酸适体R50；X
2. 谭蔚泓、刘庄、肖泽宇、孙洋；核酸类衍生物改性的核酸适体sgc8；2
3. 谭蔚泓 高飞 王若文；喜树碱衍生物及其制备方法和应用1
4. 谭蔚泓, 王若文, 张艳敏；含酚羟基的亚磷酰胺、制备方法及其应用； 2019100602193
5. 谭蔚泓, 李娟，王若文, 陈开明；用于结合曲妥珠抗体的核酸适体；201911202428.3
6. 谭蔚泓, 王若文, 孙洋；合成核酸药物偶联物的方法；2018114100677

科研奖励​

1. Ralph N. Adams生物分析化学成就奖，2019年
2. 美国PITTCON分析化学成就奖，2019年
3. 何梁何利基金科学与技术进步奖，2018年
4. 美国化学会“光谱化学分析奖”，2018年
5. 湖南省科学技术创新团队奖，2018年
6. 湖南省光召科技奖，2016年
7. 国家自然科学二等奖，2014年
8. 湖南省自然科学一等奖，2013年
9. 美国化学会Florida奖，2012年
10. 教育部自然科学一等奖，2011年