杨朝勇课题组成果

科研项目
  1. 自动化单细胞多组学分析系统 (国家重大科研仪器研制项)
  2. 循环肿瘤细胞高效分型捕获与高通量单细胞转录组测序分析 (国家基金委重点项目)
  3. 基于可控组装微纳界面的循环肿瘤细胞多维度分型富集及临床应用
  4. 生物识别材料库的构建及其制备关键技术研究(国家重点研发技术子课题)
  5. 肿瘤外泌体标志物核酸适体的筛选及其在液态活检中的应用
  6. 循环胎儿细胞的多维度富集微流控芯片的构建及在无创产前监测中的应用(国家自然科学基金委青年项目)
  7. D-型氨基酸代谢标记探针在肠道菌群研究中的应用
  8. 仿生膜界面功能化的循环肿瘤细胞捕获芯片及其临床应用(第65批中国博士后科学基金面上资助)
  9. 多重功能化微流控芯片的构建及在胎儿细胞捕获中的应用(第65批中国博士后科学基金面上资助)
  10. 基于多靶标协同识别的DNA逻辑器件用于外泌体的分离及检测(第68批中国博士后科学基金面上资助)
  11. 流动多价膜界面的构建及在肿瘤免疫治疗疗效预测中的应用
  12. 基于多孔纳米鱼骨芯片的外泌体高精准分离分析用于颅脑损伤快速诊断
发表文章
  1. Song J, Liu Y, Zhang X, Wu Q, Gao J, Wang W, Li J,* Song Y,* Yang C,* Entropy Subspace Separation-based Clustering for Noise Reduction (ENCORE) of scRNA-seq Data. Nucleic Acids Res., 2020, DOI:10.1093/nar/gkaa1157
  2. Wang W#,* Zhang Ni#, Du Y#, Gao J, Li M, Lin L, Daniel M.C, Li X,* Yang, C*&Shao Z, Three-dimensional Quantitative Imaging of Native Microbiota Distribution in the Gut. Angew. Chem. Int. Ed., 2020, DOI:10.1002/anie.202010921
  3. Lin L, Wu Q, Song J, Du Y, Gao J, Song Y, Wang W,* Yang C,* Unveiling the Indigenous Growth and Division Patterns of Bacteria in Gut Microbiota. Sci. Adv., 2020, 6, eabb2531.
  4. Wu L, Ding H, Qu X, Shi X, Yang J, Huang M, Zhang J, Zhang H, Song J, Zhu L, Song Y,* Ma Y,* Yang C,* Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability. J. Am. Chem. Soc., 2020, 142, 4800-4806.
  5. Wu L,Wang Y, Zhu L, Liu Y, Wang T, Liu D, Song Y, Yang C,* Aptamer-Based Liquid Biopsy. ACS Appl. Bio Mater., 2020, 3, 2743-2764.
  6. Song J, Zheng Y, Huang M, Wu L, Wang W, Zhu Z, Song Y,* Yang C, A Sequential Multi-dimensional Analysis Algorithm for Aptamer Identification based on Structure Analysis and Machine Learning. Anal. Chem., 2020, 92, 3307-3314.
  7. Zheng Y, Zhang J, Huang M, Wang T, Qu X, Wu L, Song J, Wang W, Song Y,* Yang C, Selection of Aptamers Against Vimentin for Isolation and Release of Circulating Tumor Cells Undergoing Epithelial Mesenchymal Transition. Anal. Chem., 2020, 92, 5178-5184.
  8. Lin L, Song J, Du Y, Wu Q, Gao J, Song Y, Yang C,* Wang W,* Quantification of Bacterial Metabolic Activities in the Gut by D-Amino Acid-based in vivo Labeling. Angew. Chem. Int. Ed., 2020, 132, 11923-11926.
  9. Zhang J, Lin B, Wu L, Huang M, Li X, Zhang H, Song J, Wang W, Zhao G*, Song Y,* Yang C,* DNA Nanolithography Enables Highly Ordered Recognition Interface in Microfluidic Chip for Efficient Capture and Release of Circulating Tumor Cells. Angew. Chem. Int. Ed., 2020, 59, 14115-14119.
  10. Zhang H, Yang Y, Liu Y, Wang Y, Ruan W, Song J, Yu X, Wu L, Zhu Z, Hong G, Yang, C,* Stimuli-Responsive Microfluidic Interface Enables Highly Efficient Capture and Release of Circulating Fetal Cells for Non-Invasive Prenatal Testing. Anal. Chem., 2020, 92, 9281-9286.
  11. Wang W#, Yang Q#, Du Y#, Zhou X, Du X, Wu Q, Lin L, Song Y, Li F, Yang C,* Tan W,* Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota. Angew. Chem. Int. Ed., 2020, 59, 2628-2633.
  12. Wang W,* Du Y, Yang S, Du X, Li M, Lin B, Zhou J,Lin L, Song Y, Li J, Zuo X,* Yang C,* Bacterial Extracellular Electron Transfer Occurs in Mammalian Gut. Anal. Chem., 2019, 91, 12138-12141.
  13. Wu L, Zhu L, Huang M, Song J, Zhang H, Song Y, Wang W, Yang C,* Aptamer-based microfluidics for isolation, release and analysis of circulating tumor cells. Trends Anal. Chem., 2019, 117, 69-77.
  14. Wu L, Xu X, Sharma B, Wang W, Qu X, Zhu L, Zhang H, Song Y, Yang C,* Beyond Capture: Circulating Tumor Cell Release and Single-Cell Analysis. Small Methods, 2019, 3, 1800544.
  15. Song Y#,* Xu Xing#, Wang W, Tian T, Zhu Z, Yang C,* Single Cell Transcriptomics: Moving towards Multi-omics. Analyst, 2019, 144, 3172-3189.
  16. Wang W, Lin L, Du Y, Song Y, Peng X, Chen X,* Yang C,* Assessing the Viability of Transplanted Gut Microbiota by Sequential Tagging with D-Amino acid-based Metabolic Probes. Nat. Commun., 2019, 10, 1317.
  17. Song Y, Shi Y, Huang M, Wang W, Wang Y, Cheng J, Lei Z, Zhu Z, Yang C,* Bioinspired Engineering of a Multivalent Aptamer-Functionalized Nanointerface to Enhance Capture and Release of Circulating Tumor Cells. Angew. Chem. Int. Ed., 2019, 58, 2236-2240.
  18. Song Y, Wu L, Yang, C,* Exosomal PD-L1: An Effective Liquid Biopsy Target to Predict Immunotherapy Response. Natl. Sci. Rev., 2019, 6,1103-1104.
  19. Song Y, Lin B, Tian T, Xu X, Wang W, Ruan Q, Guo J, Zhu Z, Yang C,* Recent Progress in Microfluidics-based Biosensing. Anal. Chem., 2018, 91, 388-404.
  20. Wang W,* Wang Y ,* Lin L, Song Y, Yang C,* A tridecaptin-based fluorescent probe for differential staining of Gram-negative bacteria. Anal. Bioanal. Chem. , 2019, 411(18): 4017-4023.
  21. Zhang H, Yang Y, Li X, Shi Y, Hu B, An Y, Zhu Z, Hong G, Yang C,*Frequency-Enhanced Transferrin receptor Antibody-Labelled Microfluidic Chip (FETAL-Chip) enables efficient enrichment of circulating nucleated red blood cells for non-invasive prenatal diagnosis. Lab Chip., 2018, 18, 2749-2756.

科研奖励

  1. 美国化学会-2021年测量科学进展讲座奖
  2. 中国化学会-英国皇家化学会青年化学奖
  3. 科技部中青年科技创新领军人才奖
  4. 中国青年分析化学家奖
  5. 中美化学与化学生物学教授协会“杰出教授奖”