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杨宇
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杨宇

上海交通大学医学院分子医学研究院研究员,博士生导师

yuyang@shsmu.edu.cn

DNA分子与纳米工程,生物材料,精准免疫治疗,智能诊疗

个人概述 / 科研方向 / 招生要求

      杨宇,上海交通大学医学院分子医学研究院研究员、博士生导师。国家高层次青年人才计划和上海市海外高层次人才计划入选者。博士毕业于澳门大学生物医药专业,随后在美国佛罗里达大学从事生物纳米技术和肿瘤免疫治疗领域的博士后研究工作。长期在生物材料、DNA分子与纳米工程、免疫工程等交叉学科领域从事研究,近年来针对肿瘤等重大疾病的诊疗,发展了一系列基于DNA分子与生物材料的光学治疗、放射治疗、靶向治疗与精准免疫治疗新策略。以第一或通讯作者在Sci. Adv.ChemJ. Am. Chem. Soc.Adv. Mater.Nano Lett.3)、ACS Nano3)、ACS Cent. Sci.2)、Biomaterials2)等国际高水平学术刊物上发表SCI文章40余篇。论文总引用3000余次,H因子325篇论文入选 “ESI高被引论文。获得澳门科技奖研究生科技研发奖(2018)、Baxter China青年研究者奖一等奖(2019),入选世界中医药学会联合会中药药剂委员会理事、中国超声医学工程学会分子影像超声专业委员会委员。

教育背景

2017至2021年            美国佛罗里达大学                      博士后

2013至2017年                   澳门大学                          生物医药博士 

工作经历

交通大学分子研究院

代表性文章 / 专利
  1. Sun Y, Mo L, Hu X, Yu D, Xie S, Li J, Zhao Z, Fang X, Ye M, Qiu L, Tan W, Yang Y*. Bispecific Aptamer-Based Recognition-then-Conjugation Strategy for PD1/PDL1 Axis Blockade and Enhanced Immunotherapy. ACS Nano. 2022 Dec 27;16(12):21129-21138.
  2.  Jia Ge, Like Yang, Zhaohui Li, Yi Wan*, Dongsheng Mao, Ruijie Deng, Qi Zhou*, Yu Yang*, Weihong Tan*. A colorimetric smartphone-based platform for pesticides detection using Fe-N/C single-atom nanozyme as oxidase mimetics. Journal of Hazardous Materials, 2022, 436:129199. (IF=14.224)
  3.  Guowang Cheng#, Xueliang Liu#, Yujing Liu, Yao Liu, Rui Ma, Jingshan Luo, Xinyi Zhou, Zhenfeng Wu, Zhuang Liu, Tongkai Chen, Yu Yang*. Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson’s Disease. Research, 2022,9781323. (IF=11.036)
  4.  Liu Y, Luo J, Liu Y, Liu W, Yu G, Huang Y, Yang Y*, Chen X, Chen T. Brain-Targeted Biomimetic Nanodecoys with Neuroprotective Effects for Precise Therapy of Parkinson’s Disease. ACS Cent Sci. 2022 Sep 28;8(9):1336-1349. (IF=12.837)
  5.  Jie Hu, Rui Chen,  Zhenglin Li, Fenzan Wu, Yanhong Yang, Yu Yang*, Xiaokun Li, Jian Xia.Polyphenol-Coordinated Supramolecular Hydrogel as a Promising “One-Stop-Shop” Strategy for Acute Infected Wound Treatment.Applied Materials Today, 2022 July 9,29.101586. (IF=10.041)
  6. Yu Yang, Bo, Liu Yuan Liu, Jingqi Chen, Yujia Sun, Xiaoshu Pan, Jun Xu, Shujuan Xu, Zhuang Liu*, and Weihong Tan*. DNA-Based MXFs to Enhance Radiotherapy and Stimulate Robust Antitumor Immune Responses[J]. Nano Letters, 2022, 22(7): 2826-2834. (IF=11.189)
  7. Xiaohao Liu, Dongsheng Mao, Yuchen Song, Liucun Zhu, Albertina N Isak, Cuicui Lu, Guoli Deng, Feng Chen, Fenyong Sun*, Yu Yang*, Xiaoli Zhu*, Weihong Tan*. Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging, Science Advances2022, 8 (2), eabk0133 (IF=14. 143)
  8. Y Yang, J Xu, Y Sun, L Mo, B Liu, X Pan, Z Liu, W Tan, Aptamer-Based Logic Computing Reaction on Living Cells to Enable Non-Antibody Immune Checkpoint Blockade Therapy. Am. Chem. Soc. 2021, 143, 22, 8391–8401 (IF= 15.419)
  9. Bo Liu, Yu Yang*, Yu Chao, Zhisheng Xiao, Jialu Xu, Chunjie Wang, Ziliang Dong, Linqian Hou, Qiaofeng Li, Zhuang Liu*; Equipping cancer cell membrane vesicles with functional DNA as a targeted-vaccine for cancer immunotherapy, Nano letters, 2021, 21(22):9410-9418 (IF=11.189)
  10. Yuan, Renyikun; Li, Yuqing; Han, Shan; Chen, Xinxin; Chen, Jingqi; He, Jia; Gao, Hongwei*; Yang, Yang; Yang*, Shilin Yang;Yang, Yu*. Fe-Curcumin Nanozyme-mediated ROS Scavenging and Anti-inflammation for Acute Lung Injury, ACS Central Science, 2021, 8, 1, 10-21. (IF=14. 553)
  11. Y Yang, WJ Zhu, ZL Dong, L Xu*, MW Chen*, Z Liu*, 1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy, Advanced Materials, 2017,10. (IF=30.8)
  12. Y Yang, Z Liu. Chemiluminescent Nanosystems for Imaging Cancer Chemodynamic Therapy. Chem, 2020, 6 (9), 2127-2129. (IF=22.804)
  13. Yang Y, Liu J, Liang C, Feng L, Fu T, Dong Z, Chao Y, Li Y, Lu G, Chen M, Liu Z. Nanoscale Metal-Organic Particles with Rapid Clearance for Magnetic Resonance Imaging-Guided Photothermal Therapy. ACS Nano, 2016, 10(2), 2774-2781. (IF= 15.881)
  14. Y Yang, XQ Sun, X Pan, W Li, S Hoda, L Li, WH Tan* Circular bispecific Aptamer-mediated targeted cellular immunotherapy. ACS Nano, 2020, 14(8): 9562-9571. (IF= 15.881)
  15. Y Yang, C Liang, WJ Zhu, Y Chao, WH Tan, MW Chen*, Z Liu* G-quadruplex based metal-organic nanoparticles as dissociable nanocarrier to modulate tumor hypoxia for effective combination therapy. Nano Letters 2018 (11), 6867-6875 (IF=11. 189)